Coated liposome formulation for oral delivery of lipid-core peptide vaccines.

• In: Symposium B4: Oral absorption of biopharmaceuticals revisited on Wednesday, 24 May 2017, 09:10-09:45
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: TOTH, Istvan (The University of Queensland, School of Chemistry and Molecular Biosciences; School of Pharmacy, Brisbane, Australia)
• Co-author(s): Istvan Toth: School of Chemistry and Molecular Biosciences; School of Pharmacy, The University of Queensland, Brisbane, Australia
  Mariusz Skwarczynski: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
  Nirmal Marasini: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
  Michael F Good: Institute of Glycomics, Griffith University, Gold Coast, Australia
  
• Abstract:

  I Background: Poor oral absorption and rapid enzymatic degradation are the major hurdles to delivering peptide drugs orally and vaccines via the mucosa. The lipid core peptide (LCP) system combines the peptide antigen, carrier, and an adjuvant in a single entity. LCP can also include synthetic lipids to enhance the immune response to poorly

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