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A modular probe strategy for drug localization, target identification and target engagement measurements on single cell level

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: RUTKOWSKA-KLUTE, Anna (Cellzome, GSK, Heidelberg, Germany)
  • Co-author(s): Anna Rutkowska-Klute: Cellzome, GSK, Heidelberg, Germany
  • Abstract:

    Late stage failures of candidate drug molecules are frequently caused by off-target effects or inefficient target engagement in vivo. In order to address these fundamental challenges in drug discovery, we have developed a modular probe strategy based on bioorthogonal chemistry which in combination with high-resolution imaging readout enables


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Last update 4 October 2019

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