A modular probe strategy for drug localization, target identification and target engagement measurements on single cell level
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Presentation
- By: RUTKOWSKA-KLUTE, Anna (Cellzome, GSK, Heidelberg, Germany)
- Co-author(s): Anna Rutkowska-Klute: Cellzome, GSK, Heidelberg, Germany
Late stage failures of candidate drug molecules are frequently caused by off-target effects or inefficient target engagement in vivo. In order to address these fundamental challenges in drug discovery, we have developed a modular probe strategy based on bioorthogonal chemistry which in combination with high-resolution imaging readout enables.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.