Intracellular unbound drug concentrations: Methodology and application for understanding cellular drug exposure
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Presentation
- By: MATEUS, André (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
- Co-author(s): André Mateus: Department of Pharmacy, Uppsala University, Uppsala, Sweden
Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden;Science for Life Laboratory Drug Discovery and Development Platform (SciLifelab-DDDP), Uppsala University, Uppsala, Sweden
The cell interior contains a large number of drug targets. Interactions with these proteins are determined by the intracellular unbound drug concentration. In this presentation, I will present a recently published methodology (Mateus et al., Mol Pharmaceutics, 2013; Mateus et al., J Med Chem, 2014) to predict drug access to intracellular targets.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.