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Intracellular unbound drug concentrations: Methodology and application for understanding cellular drug exposure

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: MATEUS, André (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
  • Co-author(s): André Mateus: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden;Science for Life Laboratory Drug Discovery and Development Platform (SciLifelab-DDDP), Uppsala University, Uppsala, Sweden
  • Abstract:

    The cell interior contains a large number of drug targets. Interactions with these proteins are determined by the intracellular unbound drug concentration. In this presentation, I will present a recently published methodology (Mateus et al., Mol Pharmaceutics, 2013; Mateus et al., J Med Chem, 2014) to predict drug access to intracellular targets


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Last update 4 October 2019

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