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Genetic polymorphisms contribute to the individual variations of Imatinib mesylate plasma levels and adverse reactions in Chinese GIST patients

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: CAI, Weimin (Fudan University, School of Pharmacy, Clinical Pharmacy, Shanghai, China)
  • Co-author(s): Jing Liu: Clinical Pharmacy, Fudan University, School of Pharmacy, Shanghai, China
    Yuhong Zhou: Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
    Hangmei Chen: Clinical Pharmacy, Fudan University, School of Pharmacy, Shanghai, China
    Weimin Cai: Clinical Pharmacy, Fudan University, School of Pharmacy, Shanghai, China
  • Abstract:

    Backgrounds

    Imatinib mesylate (IM) has been used in the treatment of  Gastrointestinal Stromal Tumors (GIST) patients. However, the clinical efficacy and adverse reactions of IM may considerably vary due to the genetic polymorphisms of its drug-metabolizing enzymes,  transporter and nuclear receptor.

    Aims

    This study aimed to investigate the influence

    ..

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Last update 4 October 2019

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