Freeze drying at room temperature to prepare protein proliposome compared to conventional granulation method
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: TUNSIRIKONGKON, Amolnat (Thammasat University, Pharmaceutical Sciences, Pathumthani, Thailand)
- Co-author(s): Amolnat Tunsirikongkon: Pharmaceutical Sciences, Thammasat University, Pathumthani, Thailand
Apinya Charernruttanakul: Pharmaceutical Sciences, Mahidol University, Bangkok, Thailand
Narong Sarisuta: Pharmaceutical Sciences, Thammasat University, Pathumthani, Thailand
Conventional method to prepare protein proliposome for tableting or capsule filling is granulation. However, the direct contact of protein with organic solvent during granulation method put forward the risk of protein integrity lost. Also, the entrapment efficiency (EE) of liposome reconstituted from granule has been observably low.
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