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New preparation method for two crystal forms of ciprofloxacin saccharinate and their photostability and hygroscopic property

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TERAOKA, Reiko (Kobe Pharmaceutical University, Pharmaceutical Technology, Kobe, Japan)
  • Co-author(s): Reiko Teraoka: Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Japan
    Misako Matsukawa: Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Japan
    Tomoko Miyazaki: Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Japan
    Reiko Yutani: Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Japan
    Chisato Tode: Analytical Laboratory, Kobe Pharmaceutical University, Kobe, Japan
    Toshiyasu Sakane: Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Japan
  • Abstract:

    Backgrounds

    Fluoroquinolone antibiotics are known to be degraded by exposure to light. Two crystal forms of ciprofloxacin saccharinate (CIP-Sac) was isolated 1, 2).

    1) C.B. Romañuk et al., J. Pharm. Sci., 98, 3788–3801 (2009).


    2) C.B. Romañuk et al., Int.J. Pharm., 391, 197–202 (2010).

    Aims

    The purpose of the present study was to develop a new



    ..

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Last update 4 October 2019

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