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Prediction of food effect on intestinal drug absorption: Development and evaluation of a new in silico physiological fed state model in GI-Sim
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: KARLSSON, Eva (AstraZeneca, Operations, Mölndal, Sweden)
- Co-author(s): Anneli Angerfors: Pharmaceutical technology and development, AstraZeneca, Mölndal, Sweden
Christer Tannergren: Pharmaceutical technology and development, AstraZeneca, Mölndal, Sweden
Erik Sjögren: Department of Pharmacy, Uppsala University, Uppsala, Sweden
Eva Karlsson: Pharmaceutical technology and development, AstraZeneca, Mölndal, Sweden
BackgroundsPhysiologically based in silico models are widely used in the pharmaceutical industry for prediction of in vitro and in vivo drug performance. The models are continuously improved with increased knowledge of the gastrointestinal (GI) physiology and drug absorption process.
AimsThe aim of the present study was to develop and evaluate an i.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019