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Prediction of food effect on intestinal drug absorption: Development and evaluation of a new in silico physiological fed state model in GI-Sim

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: KARLSSON, Eva (AstraZeneca, Operations, Mölndal, Sweden)
  • Co-author(s): Anneli Angerfors: Pharmaceutical technology and development, AstraZeneca, Mölndal, Sweden
    Christer Tannergren: Pharmaceutical technology and development, AstraZeneca, Mölndal, Sweden
    Erik Sjögren: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Eva Karlsson: Pharmaceutical technology and development, AstraZeneca, Mölndal, Sweden
  • Abstract:

    Backgrounds

    Physiologically based in silico models are widely used in the pharmaceutical industry for prediction of in vitro and in vivo drug performance. The models are continuously improved with increased knowledge of the gastrointestinal (GI) physiology and drug absorption process.

    Aims

    The aim of the present study was to develop and evaluate an i

    ..

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Last update 4 October 2019

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