Biorelevant tests combined with a Physiologically Based Pharmacokinetic Model predict the in vivo behaviour of Ciprofloxacin
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: HANSMANN, Simone (Goethe University, Institute of Pharmaceutical Technology, Frankfurt, Germany)
- Co-author(s): Simone Hansmann: Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
Jennifer Dressman: Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
BackgroundsPhysiologically based Pharmacokinetic Models
The aim of this study was 1) to investigate the behaviour of ciprofloxacin, a BCS Class IV weakly basic drug, under conditions simulating the upper GI tract in humans using in vitro dissolution in single media, in a two-stage method and in transfer experiments and 2) to simulate the plasma.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.