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Biorelevant tests combined with a Physiologically Based Pharmacokinetic Model predict the in vivo behaviour of Ciprofloxacin

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HANSMANN, Simone (Goethe University, Institute of Pharmaceutical Technology, Frankfurt, Germany)
  • Co-author(s): Simone Hansmann: Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
    Jennifer Dressman: Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
  • Abstract:

    Backgrounds

    Physiologically based Pharmacokinetic Models

    Aims

    The aim of this study was 1) to investigate the behaviour of ciprofloxacin, a BCS Class IV weakly basic drug, under conditions simulating the upper GI tract in humans using in vitro dissolution in single media, in a two-stage method and in transfer experiments and 2) to simulate the plasma

    ..

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Last update 4 October 2019

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