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Enhanced stability and super-saturation of felodipine amorphous solid dispersions

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: FERRAND-DRAKE, Gustav (Göteborg, Sweden)
  • Co-author(s): Gustav Ferrand-Drake: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Aleksandar Matic: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Joel Wanemark: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Josef Rizell: Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
    Anna Viridén: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Hanna Matic: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Anders Borde: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Johan Breitholz: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
    Anette Larsson: Applied Chemistry, Chalmers University of Technology, Gothenburg, Sweden
    Susanna Abrahamsén-Alami: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden
  • Abstract:

    Backgrounds


    Amorphous Solid Dispersions (ASD) improve the dissolution rate and gives rise to super-saturation of otherwise insufficiently soluble crystalline pharmaceuticals. For ASDs to be viable there must be sufficient stability of the amorphous pharmaceutical against crystallization during oral administration and during storage. It is not known


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Last update 4 October 2019

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