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Drying and tableting of low water-soluble nanocrystals to improve oral bioavailability

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BRAIG, Veronika (Erlangen, Germany)
  • Co-author(s): Veronika Braig: Division of Pharmaceutics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
    Christoph Konnerth: Institute of Particle Technology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
    Wolfgang Peukert: Institute of Particle Technology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
    Geoffrey Lee: Division of Pharmaceutics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
  • Abstract:

    Backgrounds

    The production of nanocrystals is a strategy to improve the low aqueous solubility of drugs. Following, specific surface and dissolution rate are increased and oral bioavailability is improved. Before being packed into a solid dosage form, nanosuspensions have to be embedded into a dry powder due to stability problems and to increase

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Last update 4 October 2019

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