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Drug distribution to retinal pigment epithelium: studies on melanin binding, cellular kinetics and SPECT/CT imaging

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: RIMPELä, Anna-Kaisa (University of Helsinki, Division of Pharmaceutical Biosciences, Helsinki, Finland)
  • Co-author(s): Anna-Kaisa Rimpelä: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
    Mechthild Schmitt: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
    Satu Latonen: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
    Marja Hagström: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
    Maxim Antopolsky: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
    Jose Manzanares: Department of Thermodynamics, University of Valencia, Valencia, Spain
    Heidi Kidron: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
    Arto Urtti: Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland
  • Abstract:

    Backgrounds

    Melanin binding in the eye is known to affect the distribution of ocular drugs.

    Aims

    The purpose of this study was to evaluate if the extent of drug uptake to primary retinal pigment epithelial (RPE) cells could be estimated based on in vitro binding studies with isolated melanin and if single photon emission computed tomography/computed

    ..

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Last update 4 October 2019

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