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Polymer-functionalized Silica-Lipid Hybrid for Improving the Oral Delivery of Poorly Water-Soluble Weak Base Drugs

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: RAO, Shasha (University of South Australia, School of Pharmacy and Medical Sciences, Adelaide, Australia)
  • Co-author(s): Shasha Rao: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Katharina Richter: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Tri-Hung Nguyen: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
    Ben Boyd: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Australia
    Christopher Porter: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Australia
    Angel Tan: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Clive Prestidge: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
  • Abstract:

    Backgrounds

    Silica lipid hybrid (SLH) microparticles are an efficient solid-state lipid-based carrier for the oral delivery of poorly water-soluble compounds.

    Aims

    This study focuses on combining the advantages of SLH with the benefits of Pluronic (Plu) F127 to control lipid digestion and drug release, hence enhancing the oral absorption.

    Methods

    Cinnar

    ..

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Last update 4 October 2019

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