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Combining Lipophilic Prodrugs and Nanomedicines to Facilitate Oral Chemotherapy

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: PRESTIDGE, Clive (University of South Australia, School of Pharmacy & Medical Sciences, Adelaide, Australia)
  • Co-author(s): Clive Prestidge: School Pharmacy, UniSA, Adelaide, Australia
    Vaskor Bala: School Pharmacy, UniSA, Adelaide, Australia
    Shasha Rao: School Pharmacy, UniSA, Adelaide, Australia
  • Abstract:


    Irinotecan is a water soluble prodrug of SN38 (7-ethyl-10-hydroxy camptothecin) used in advance colorectal cancer therapy and dosed by intravenous infusion. Its application is dose limited due to gastro-intestinal toxicity. Furthermore, a number of pharmaceutical and pharmacological challenges conspire to limit the oral absorption of..

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Last update 4 October 2019

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