Combining Lipophilic Prodrugs and Nanomedicines to Facilitate Oral Chemotherapy

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-105-Tuesday
• By: PRESTIDGE, Clive (University of South Australia, School of Pharmacy & Medical Sciences, Adelaide, Australia)
• Co-author(s): Clive Prestidge: School Pharmacy, UniSA, Adelaide, Australia
  Vaskor Bala: School Pharmacy, UniSA, Adelaide, Australia
  Shasha Rao: School Pharmacy, UniSA, Adelaide, Australia
  
• Abstract:

  Backgrounds

  Irinotecan is a water soluble prodrug of SN38 (7-ethyl-10-hydroxy camptothecin) used in advance colorectal cancer therapy and dosed by intravenous infusion. Its application is dose limited due to gastro-intestinal toxicity. Furthermore, a number of pharmaceutical and pharmacological challenges conspire to limit the oral absorption of..

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