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Dry Naked pDNA inhalation powder composed of hyaluronic acid exhibits high gene expression in the lungs.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ITO, Takaaki (Meijo University, Graduate School of Pharmaceutical Sciences, Nagoya City, Japan)
  • Co-author(s): Takaaki Ito: Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya City, Japan
    Tomoyuki Okuda: Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya City, Japan
    Hirokazu Okamoto: Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya City, Japan
  • Abstract:

    Backgrounds

    Cationic polymers have been studied as non-viral gene delivery vectors to suppress degradation of pDNA by nucleolytic enzymes and to increase gene expression in vivo. However, it is often the case that the addition of a vector results in adverse effects. Recently, we found that dry naked pDNA powders including no vector showed excellent ..

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Last update 4 October 2019

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