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Dry Naked pDNA inhalation powder composed of hyaluronic acid exhibits high gene expression in the lungs.
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: ITO, Takaaki (Meijo University, Graduate School of Pharmaceutical Sciences, Nagoya City, Japan)
- Co-author(s): Takaaki Ito: Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya City, Japan
Tomoyuki Okuda: Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya City, Japan
Hirokazu Okamoto: Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya City, Japan
BackgroundsCationic polymers have been studied as non-viral gene delivery vectors to suppress degradation of pDNA by nucleolytic enzymes and to increase gene expression in vivo. However, it is often the case that the addition of a vector results in adverse effects. Recently, we found that dry naked pDNA powders including no vector showed excellent .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019