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Structure-Pharmacokinetic Relationships of L-Type Amino Acid Transporter 1 (LAT1)- Utilizing Prodrugs of Ketoprofen in Mice

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HUTTUNEN, Kristiina (University of Eastern Finland, School of Pharmacy, Kuopio, Finland)
  • Co-author(s): Kristiina M. Huttunen: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    Elena Puris: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    Johanna Huttunen: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    Aleksanteri Petsalo: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    Mikko Gynther: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
  • Abstract:

    Backgrounds

    L-Type amino acid transporter 1 (LAT1) is highly and selectively expressed in the blood-brain barrier (BBB) and brain parenchyma. Therefore, utilizing LAT1 offers an opportunity to target (pro)drugs into the brain to improve their efficacy and safety profile. 

    Aims

    The aim of this study was to synthesize five LAT1-utilizing prodrugs of

    ..

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Last update 4 October 2019

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