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The Impact of Liposomal Formulations Based on Different Phospholipids on the In Vivo Release and Brain Delivery of Methotrexate: A Microdialysis Study

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HU, Yang (Uppsala University, Department of Pharmaceutical Biosciences, Uppsala, Sweden)
  • Co-author(s): Yang Hu: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Jaap Rip: Eyesiu Medicine B.V., Leiden, Netherlands
    Pieter J Gaillard: 2-BBB Medicine B.V., Leiden, Netherlands;, Eyesiu Medicine B.V., Leiden, Netherlands
    Elizabeth de Lange: Division of Pharmacology, Leiden University, Leiden, Netherlands
    Margareta Hammarlund-Udenaes: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    The composition of liposomes may be an important factor influencing the in vivo “fate” of the drug cargo. However, the formulation impact in vivo, particularly on brain uptake of the cargo is poorly understood from a quantitative perspective.

    Aims

    To quantitatively assess the impact of liposomal formulations on the in vivo release and

    ..

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Last update 4 October 2019

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