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The Impact of Liposomal Formulations Based on Different Phospholipids on the In Vivo Release and Brain Delivery of Methotrexate: A Microdialysis Study
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: HU, Yang (Uppsala University, Department of Pharmaceutical Biosciences, Uppsala, Sweden)
- Co-author(s): Yang Hu: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Jaap Rip: Eyesiu Medicine B.V., Leiden, Netherlands
Pieter J Gaillard: 2-BBB Medicine B.V., Leiden, Netherlands;, Eyesiu Medicine B.V., Leiden, Netherlands
Elizabeth de Lange: Division of Pharmacology, Leiden University, Leiden, Netherlands
Margareta Hammarlund-Udenaes: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
BackgroundsThe composition of liposomes may be an important factor influencing the in vivo “fate” of the drug cargo. However, the formulation impact in vivo, particularly on brain uptake of the cargo is poorly understood from a quantitative perspective.
AimsTo quantitatively assess the impact of liposomal formulations on the in vivo release and.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019