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Preparation of self-assembled siRNA-PLGA hybrid conjugate micelles as GPC-3 gene silencing therapy for ovarian cancer

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HAZEKAWA, Mai (Fukuoka University,, Department of Immunological and Molecular Pharmacology, FUKUOKA, Japan)
  • Co-author(s): Mai Hazekawa: Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, FUKUOKA, Japan
    Masahiko Morioka: Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, FUKUOKA, Japan;Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, FUKUOKA, Japan
    Takuya Nishinakagawa: Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, FUKUOKA, Japan
    Tomoyo Kawakubo-Yasukochi: Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, FUKUOKA, Japan
    Seiji Nakamura: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, FUKUOKA, Japan
    Manabu Nakashima: Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, FUKUOKA, Japan
  • Abstract:

    Backgrounds

    Ovarian cancer is the most lethal gynecologic cancer in the Western world. Recently, it has been reported that GPC-3 gene was overexpressed specifically in ovarian cancer. We focused on availability of GPC-3 gene silencing for ovarian cancer therapy used by siRNA delivery systems.

    Aims

    The purpose of this study was preparation of

    ..

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Last update 4 October 2019

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