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Lipid mimetic, lymph-directing prodrugs of testosterone facilitate oral bioavailability via avoidance of first-pass metabolism

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HU, Luojuan (Monash University, Faculty of Pharmacy and Pharmaceutical Sciences, Melbourne, Australia)
  • Co-author(s): Luojuan Hu: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Sifei Han: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Tim Quach: Medicinal Chemistry, Monash University, Melbourne, Australia
    Shea Lim: Medicinal Chemistry, Monash University, Melbourne, Australia
    Natalie Trevaskis: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Jamie Simpson: Medicinal Chemistry, Monash University, Melbourne, Australia
    Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  • Abstract:

    Backgrounds

    Hepatic first-pass metabolism limits the oral bioavailability of drugs such as testosterone (TST). Drug transport through the lymphatic system avoids first pass metabolism since intestinal lymph drains into the systemic circulation via the thoracic duct, bypassing the liver. Dietary triglyceride (TG) is transported via the lymphatics

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Last update 4 October 2019

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