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siRNA loaded pH-responsive and Tumor-targeted Nano-carries for Inhibiting Tumor Growth and Metastasis in Cancer therapy

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: GAO, Zhonggao (Chinese Academy of Medical Sciences, Pharmaceutics, Beijing, China)
  • Co-author(s): Zhonggao Gao: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
    Bo Fan: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
    Wei Huang: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
    Lin kang: Pharmaceutics, Chinese Academy of Medical Sciences, Beijing, China
  • Abstract:

    Backgrounds

    A novel pH-activated “sheddable” PEG-coated nanoparticle was constructed for effective treatment of primary tumors and metastases, which was based on the conjugation of catechol group modified poly(ethylene glycol) (PEG-Cat) and PBA-terminated polyethylenimine (PEI-PBA) via the borate ester formed between PBA and Cat.

    Aims

    To prepare dual

    ..

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Last update 4 October 2019

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