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Effects of silymarin on the pharmacokinetics of carbamazepine, oxcarbazepine, phenytoin and their main metabolites in rats

  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • By: FERREIRA, Ana Filipa (University of Beira Interior, Health Sciences Research Centre, Covilhã, Portugal)
  • Co-author(s): Ana Filipa Ferreira: Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal;Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Márcio Rodrigues: Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal;Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda, Portugal
    Amílcar Falcão: Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal;Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
    Gilberto Alves: Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal;Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
  • Abstract:

    Backgrounds

    The pharmacoresistance stills affecting 30-40% of the epileptic patients, being P-glycoprotein (P-gp) recognised as one of the primary mechanism involved. In an attempt to find potent and safer P-gp inhibitors, a particular emphasis has been given to flavonoid compounds, as silymarin, to be potentially used as add-on therapy. 

    Aims

    To asse

    ..

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Last update 4 October 2019

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