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Impact of lipids on intracellular bioavailability

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TREYER, Andrea (Uppsala University, Pharmacy, Uppsala, Sweden)
  • Co-author(s): Andrea Treyer: Pharmacy, Uppsala University, Uppsala, Sweden
    André Mateus: Pharmacy, Uppsala University, Uppsala, Sweden
    Hinnerk Boriss: Sovicell GmbH, Leipzig, Germany
    Pär Matsson: Pharmacy, Uppsala University, Uppsala, Sweden
    Per Artursson: Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Intracellular unbound drug concentration (Cu,cell) drives pharmacological and toxicological responses for targets inside cells. However, the mechanisms that drive cellular drug binding are not so well understood.

    Aims

    The aim of this study was to evaluate drug binding to two cellular components - neutral lipids and phospholipids.

    Methods

    Bin

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Last update 4 October 2019

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