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Factors affecting intestinal drug permeation in-vitro: rat intestinal tissue vs. artificial membrane

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: RIETHORST, Danny (KULeuven, Drug delivery and disposition, Leuven, Belgium)
  • Co-author(s): Danny Riethorst: Drug delivery and disposition, KULeuven, Leuven, Belgium
    Patrick Augustijns: Drug delivery and disposition, KULeuven, Leuven, Belgium
    Jens Motmans: Drug delivery and disposition, KULeuven, Leuven, Belgium
    Joachim Brouwers: Drug delivery and disposition, KULeuven, Leuven, Belgium
  • Abstract:

    Backgrounds

    Nowadays the majority of new drugs and drug candidates are lipophilic and interactions with intestinal fluid colloids are becoming more important for absorption. Ussing chambers experiments using rat intestine have shown that fed state media decrease permeation of lipophilic drugs; this effect appeared more pronounced in fed state human

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Last update 4 October 2019

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