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Polyethyleneimine Complex with Alendronate Increases Intestinal Permeation of this Bisophosphonate Drug in vitro

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: PAULETTI, Giovanni (University of Cincinnati, Winkle College of Pharmacy, Cincinnati, United States)
  • Co-author(s): Basma Abd El-Hamid: Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Giovanni Pauletti: Winkle College of Pharmacy, University of Cincinnati, Cincinnati, United States
  • Abstract:

    Backgrounds

    Unfavorable physicochemical properties of the anti-osteoporotic drug alendronate (AL) limit oral bioavailability in humans to ≤1% when administered using conventional oral dosage forms.

    Aims

    The main objective of this research is to prepare a lipid-based nanodelivery system that enhances the flux of this highly polar drug across the

    ..

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Last update 4 October 2019

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