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Polyethyleneimine Complex with Alendronate Increases Intestinal Permeation of this Bisophosphonate Drug in vitro
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: PAULETTI, Giovanni (University of Cincinnati, Winkle College of Pharmacy, Cincinnati, United States)
- Co-author(s): Basma Abd El-Hamid: Faculty of Pharmacy, Assiut University, Assiut, Egypt
Giovanni Pauletti: Winkle College of Pharmacy, University of Cincinnati, Cincinnati, United States
BackgroundsUnfavorable physicochemical properties of the anti-osteoporotic drug alendronate (AL) limit oral bioavailability in humans to ≤1% when administered using conventional oral dosage forms.
AimsThe main objective of this research is to prepare a lipid-based nanodelivery system that enhances the flux of this highly polar drug across the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019