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Biometals regulate the expression and function of P-glycoprotein at the blood-brain barrier

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NICOLAZZO, Joseph (Monash University, Drug Delivery, Disposition and Dynamics, Parkville, Australia)
  • Co-author(s): Joseph Nicolazzo: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Mitchell McInerney: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
    Jennifer Short: Drug Discovery Biology, Monash University, Parkville, Australia
  • Abstract:

    Backgrounds

    The biometals copper (Cu2+) and zinc (Zn2+) are essential for normal brain health and any imbalance in their levels leads to neurological disease. The role of these biometals in the health of the blood-brain barrier (BBB), however, has received little attention.

    Aims

    To assess the impact of Cu2+ and Zn2+ on the expression and function of

    ..

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Last update 4 October 2019

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