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Ussing chambers for the study of nanoparticle permeability in the human jejunum

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: LUNDQUIST, Patrik (Uppsala University, Pharmacy, Uppsala, Sweden)
  • Co-author(s): Patrik Lundquist: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Georgiy Khodus: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Ivailo Simoff: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Lungile Thwala: Dept. of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain
    Zhigao Niu: Dept. of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain
    Dominic-Luc Webb: Department of Medical Sciences, Gastroenterology/Hepatalogy, Uppsala University, Uppsala, Sweden
    Per Hellström: Department of Medical Sciences, Gastroenterology/Hepatalogy, Uppsala University, Uppsala, Sweden
    Magnus Sundbom: Department of Surgical Sciences, Upper Abdominal Surgery, Uppsala University, Uppsala, Sweden
    Åsa Keita: Department of Clinical and Experimental Medicine (IKE) / Division of Clinical Sciences (KLINV), Linköping University, Linköping, Sweden
    Noemi Csaba: Dept. of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain
    María José Alonso: Dept. of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain
    Mikael Wiren: Department of Clinical and Experimental Medicine (IKE) / Division of Clinical Sciences (KLINV), Linköping University, Linköping, Sweden
    Johan Dabrosin Söderholm: Department of Clinical and Experimental Medicine (IKE) / Division of Clinical Sciences (KLINV), Linköping University, Linköping, Sweden
    Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Oral delivery of peptide drugs and biopharmaceutics remains a challenge. A possible way to achieve improved bioavailability of such drugs after oral administration could be to encapsulate the molecules in a nanoparticle that protects them from the harsh environment of the gastrointestinal tract and aids their penetration of the..

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Last update 4 October 2019

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