The use of Caco-2 cells to evaluate drug absorption from lipid-based formulations
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: KEEMINK, Janneke (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
- Co-author(s): Janneke Keemink: Department of Pharmacy, Uppsala University, Uppsala, Sweden
Christel A.s Bergström: Department of Pharmacy, Uppsala University, Uppsala, Sweden
An increasing number of drug candidates exhibit low solubility. Lipid-based formulations (LBFs) are used to enhance solubility of these compounds in the GI tract. Typically in vitro digestion is used to evaluate the LBF performance prior to in vivo studies.
To evaluate the conditions that allow the use of Caco-2 monolayers in the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.