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Expression of drug transporters in 150 human liver samples

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HANDIN, Niklas (Uppsala, Sweden)
  • Co-author(s): Niklas Handin: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Fabienne Gaugaz: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Anne Nies: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Germany
    Elke Schaeffeler: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Germany
    Kathrin Klein: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Germany
    Ulrich M. Zanger: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Germany
    Matthias Schwab: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Germany;Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital of Tübingen, Tübingen, Germany
    Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    The pharmacokinetic profiles of drugs that are substrates of transport proteins will vary with the concentration of the transporters so that their accurate quantification are therefore of great importance.

    Aims

    To quantify important solute carrier (SLC)- and ATP-binding cassette (ABC)-transport proteins in 150 human liver samples and

    ..

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Last update 4 October 2019

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