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Investigation of pulmonary drug permeability and tissue retention by computational analysis of rat ex vivo lung absorption profiles

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ERIKSSON, Johanna (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
  • Co-author(s): Johanna Eriksson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Erik Sjögren: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Helena Thörn: Pharmaceutical Development Inhalation, AstraZeneca-Gothenburg, Gothenburg, Sweden
    Katarina Rubin: Respiratory, Inflammation and Autoimmunity, Innovative Medicine and Early Development, AstraZeneca-Gothenburg, Gothenburg, Sweden
    Per Bäckman: Current adress: Mylan Global Respiratory Group, Mylan Pharma UK Ltd, Kent, United Kingdom;Pharmaceutical Development Inhalation, AstraZeneca-Gothenburg, Gothenburg, Sweden
    Hans Lennernäs: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    To achieve an optimal drug delivery to the lung by pharmaceutical formulation it is important to have knowledge not only about residence time and drug release, but also of the rate and mechanisms of pulmonary permeability and tissue retention processes.

    Aims

    The aim of this study was to investigate the overall pulmonary absorption of drug

    ..

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Last update 4 October 2019

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