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Displacement of itraconazole from cyclodextrin complexes in biorelevant media
- At: Stockholm (Sweden) (2017)
- Type: Poster
- By: STAPPAERTS, Jef (KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium)
- Co-author(s): Jef Stappaerts: Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
Patrick Augustijns: Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
Intestinal fluids contain several constituents with affinity for cyclodextrins and therefore have the potential of displacing drugs from the cyclodextrin cavity by competition.
AimsThe aim of the study was to evaluate the solubilizing capacity of HP-β-CD for itraconazole in presence of varying biorelevant concentrations of bile salts and .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019