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Displacement of itraconazole from cyclodextrin complexes in biorelevant media

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: STAPPAERTS, Jef (KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium)
  • Co-author(s): Jef Stappaerts: Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
    Patrick Augustijns: Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
  • Abstract:

    Backgrounds

    Intestinal fluids contain several constituents with affinity for cyclodextrins and therefore have the potential of displacing drugs from the cyclodextrin cavity by competition.

    Aims

    The aim of the study was to evaluate the solubilizing capacity of HP-β-CD for itraconazole in presence of varying biorelevant concentrations of bile salts and

    ..

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Last update 4 October 2019

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