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Changes in Indomethacin Solubility in Mixtures with Basic Drugs

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SHIMADA, Yohsuke (Tokyo University of Science, Faculty of Pharmaceutical Sciences, Noda, Japan)
  • Co-author(s): Yohsuke Shimada: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    Ryo Tateuchi: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    Satoru Goto: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
  • Abstract:

    Backgrounds

    A mixture of indomethacin (IND), an acidic nonsteroidal anti-inflammatory drug, and lidocaine (LID), a local anesthetic (LA), forms a eutectic complex, which has a low melting point that is near room temperature. The aqueous solubility of the mixture is greater than that of IND or LID alone, improving the bioavailability of IND. 

    Aims

    Ther

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Last update 4 October 2019

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