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Preparation and evaluation of doxorubicin-loaded human serum albumin nanoparticles

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: KIMURA, Kotaro (Kumamoto, Japan)
  • Co-author(s): Kotaro Kimura: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Keishi Yamasaki: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;DDS Resarch Institute, Sojo University, Kumamoto, Japan
    Kazuaki Taguchi: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Hideaki Nakamura: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Mamoru Haratake: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Masaki Otagiri: Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;DDS Resarch Institute, Sojo University, Kumamoto, Japan
  • Abstract:

    Backgrounds

    Human serum albumin (HSA) has been shown to be biocompatible and bind vriety of drugs. Therefore, it is ideal as a carrier of a drug in cancer therapy. In cancer treatment using carriers, it is known that nanoparticles showing a size of 60 to 130 nm exhibit high tumor accumulation due to the EPR (enhanced permeability and retention)..

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Last update 4 October 2019

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