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Hydrodynamic Influences on Drug Dissolution and Absorption In Vitro and In Vivo, quantified with Mathematical Models and Computer Simulation

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BRASSEUR, James (University of Colorado Boulder, Aerospace Engineering Sciences, Boulder, CO, United States)
  • Co-author(s): James Brasseur: Aerospace Engineering Sciences, University of Colorado Boulder, Boulder, CO, United States
    Farhad Behafarid: Aerospace Engineering Sciences, University of Colorado Boulder, Boulder, CO, United States
    Yanxing Wang: Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA, United States
    Deanna Mudie: Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, United States
    Gregory Amidon: Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, United States
  • Abstract:

    Backgrounds

    Dissolution and absorption occurs within intestinal lumina filled with fluid motions driven by contractions of intestinal muscle.

    Aims

    We contrast hydrodynamic influences on dissolution from distributions of drug particles in the upper intestines with motility and absorption, with dissolution in the impermeable USP II vessel.

    Methods

    We

    ..

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Last update 4 October 2019

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