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Assessment of passive intestinal permeability for poorly water soluble drugs: Caco-2 cells versus artificial membrane
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: BERBEN, Philippe (KU Leuven, Drug Delivery and Disposition, Leuven, Belgium)
- Co-author(s): Philippe Berben: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
Joachim Brouwers: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
Patrick Augustijns: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
BackgroundsDespite reasonable predictive power of current (non)-cell-based absorption systems for the prediction of intestinal drug permeability, high costs and lengthy preparation steps hamper their use, especially in combination with dissolution testing for the evaluation of formulations.
AimsTo evaluate the use of a simple artificial membrane.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019