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Assessment of passive intestinal permeability for poorly water soluble drugs: Caco-2 cells versus artificial membrane

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: BERBEN, Philippe (KU Leuven, Drug Delivery and Disposition, Leuven, Belgium)
  • Co-author(s): Philippe Berben: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
    Joachim Brouwers: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
    Patrick Augustijns: Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
  • Abstract:

    Backgrounds

    Despite reasonable predictive power of current (non)-cell-based absorption systems for the prediction of intestinal drug permeability, high costs and lengthy preparation steps hamper their use, especially in combination with dissolution testing for the evaluation of formulations. 

    Aims

    To evaluate the use of a simple artificial membrane

    ..

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Last update 4 October 2019

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