Effects of silymarin and (-)-epigallocatechin gallate on the pharmacokinetics of oxcarbazepine in rats
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: FERREIRA, Ana Filipa (University of Beira Interior, Health Sciences Research Centre, Covilhã, Portugal)
- Co-author(s): Ana Filipa Ferreira: Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal;Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
Márcio Rodrigues: Health Sciences Research Centre, University of Beira Interior
The interest in flavonoids as P-glycoprotein (P-gp) inhibitors has gained relevance over the last years, particularly to overcome the P-gp–mediated multidrug resistance, which is clinically important in epilepsy.
To evaluate the effects of silymarin and (-)-epigallocatechin gallate (EPG) in improving the pharmacokinetics of oxcarbazep.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.