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Effects of silymarin and (-)-epigallocatechin gallate on the pharmacokinetics of oxcarbazepine in rats

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: FERREIRA, Ana Filipa (University of Beira Interior, Health Sciences Research Centre, Covilhã, Portugal)
  • Co-author(s): Ana Filipa Ferreira: Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal;Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Márcio Rodrigues: Health Sciences Research Centre, University of Beira Interior
  • Abstract:

    Backgrounds

    The interest in flavonoids as P-glycoprotein (P-gp) inhibitors has gained relevance over the last years, particularly to overcome the P-gp–mediated multidrug resistance, which is clinically important in epilepsy.

    Aims

    To evaluate the effects of silymarin and (-)-epigallocatechin gallate (EPG) in improving the pharmacokinetics of oxcarbazep

    ..

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Last update 4 October 2019

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