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Molecular association model of Peroxisome Proliferator-Activated Receptor α and its new specific and efficient ligand, K-877

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TOKIWA, Hiroaki (Rikkyo Universiry, Department of Chemistry, Tokyo, Japan)
  • Co-author(s): Yurina Miyashita: Department of Chemistry, Rikkyo Universiry, Tokyo, Japan;AMED-CREST, JST, Tokyo, Japan
    Kenta Takei: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan
    Vladimir Sladek: Department of Chemistry, Rikkyo Universiry, Tokyo, Japan;AMED-CREST, JST, Tokyo, Japan
    Shogo Nakano: Department of Food Sciences, University of Shizuoka, Shizuoka, Japan;AMED-CREST, JST, Tokyo, Japan
    Shohei Ito: Department of Food Sciences, University of Shizuoka, Shizuoka, Japan;AMED-CREST, JST, Tokyo, Japan
    Takeshi Matsuzaka: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
    Motohiro Sekiya: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
    Yoshimi Nakagawa: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
    Hiroaki Tokiwa: Department of Chemistry, Rikkyo Universiry, Tokyo, Japan;AMED-CREST, JST, Tokyo, Japan
    Hitoshi Shimano: Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan;AMED-CREST, JST, Tokyo, Japan
  • Abstract:

    Backgrounds

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of  nuclear receptor superfamily.  PPARα is a regulator that activates fatty acid oxidation and improves hypertriglyceridemia.  K-877 is a novel selective PPARα modulator (SPPARMα) to activate PPARα transcriptional activity. 

    Aims

    The main

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Last update 4 October 2019

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