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Anti-metastatic effect of Clopidogrel is associated with inhibition of invasiveness in B16-BL6 mouse melanoma cells

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: YOSHIKAWA, Noriko (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Pharmacology I, Nishinomiya, Japan)
  • Co-author(s): Noriko Yoshikawa: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    Mayuko Hatai: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    Eriko Kinoshita: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    Satomi Kagota: Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    Kazumasa Shinozuka: Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    Kazuki Nakamura: Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
  • Abstract:

    Backgrounds

    Clopidogrel, a derivative of thienopyridine, inhibits platelet aggregation through the inhibition of P2Y12 receptor, then used to reduce the risk of heart disease and stroke. We previously demonstrated that orally administered Clopidogrel inhibited lung metastasis in mice intravenously injected with B16-BL6 mouse melanoma cells.

    Aims

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Last update 4 October 2019

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