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Application of virtual clinical studies using physiologically-based pharmacokinetic model to analyses of the association of side effects of CPT-11 with genetic polymorphism of enzymes and transporters

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: TOSHIMOTO, Kota (Yokohama, Japan)
  • Co-author(s): Kota Toshimoto: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Japan
    Atsuko Tomaru: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Japan
    Masakiyo Hosokawa: Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Japan
    Yuichi Sugiyama: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Japan
  • Abstract:

    Backgrounds

    Many controversial associations between various genetic polymorphisms and side effects of CPT-11 (neutropenia and diarrhea) have been reported.

    Aims

    The purpose of this study is to develop a physiologically-based pharmacokinetic (PBPK) model to gain insight into the factors associated with side effects of CPT-11 using a virtual clinical

    ..

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Last update 4 October 2019

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