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Application of virtual clinical studies using physiologically-based pharmacokinetic model to analyses of the association of side effects of CPT-11 with genetic polymorphism of enzymes and transporters
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: TOSHIMOTO, Kota (Yokohama, Japan)
- Co-author(s): Kota Toshimoto: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Japan
Atsuko Tomaru: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Japan
Masakiyo Hosokawa: Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Japan
Yuichi Sugiyama: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Japan
BackgroundsMany controversial associations between various genetic polymorphisms and side effects of CPT-11 (neutropenia and diarrhea) have been reported.
AimsThe purpose of this study is to develop a physiologically-based pharmacokinetic (PBPK) model to gain insight into the factors associated with side effects of CPT-11 using a virtual clinical .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019