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Effect of Drug Uptake Transporters on Fluvastatin Pharmacokinetics in Rats

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: OKOCHI, Hideaki (UCSF, BTS, SAN FRANCISCO, United States)
  • Co-author(s): Hideaki Okochi: Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, United States
    Leslie Benet: Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, United States
  • Abstract:

    Backgrounds

    Fluvastatin (FLST), a highly hydrophilic and extensively metabolized HMG-CoA reductase inhibitor, is categorized as Biopharmaceutical Drug Disposition Classification class 1 and suggested not to be affected by drug transporters in in vivo pharmacokinetics (PK). However, the Extended Clearance Classification System suggests that FLST, an

    ..

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Last update 4 October 2019

FIP Congresses