Effect of Drug Uptake Transporters on Fluvastatin Pharmacokinetics in Rats
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Poster
- By: OKOCHI, Hideaki (UCSF, BTS, SAN FRANCISCO, United States)
- Co-author(s): Hideaki Okochi: Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, United States
Leslie Benet: Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, United States
Fluvastatin (FLST), a highly hydrophilic and extensively metabolized HMG-CoA reductase inhibitor, is categorized as Biopharmaceutical Drug Disposition Classification class 1 and suggested not to be affected by drug transporters in in vivo pharmacokinetics (PK). However, the Extended Clearance Classification System suggests that FLST, an.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.