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Drug-target binding influences target- and tissue selectivity.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: DE WITTE, Wilbert (Leiden Academic Centre for Drug Research, Pharmacology, Leiden, Netherlands)
  • Co-author(s): Wilhelmus E. A. de Witte: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Hendrika C. Vlot: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Piet H. van der Graaf: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands;Quantitative Systems Pharmacology, Certara, Canterbury, United Kingdom
    Meindert Danhof: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Gerard J. P. van Westen: Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden, Netherlands
    Elizabeth C. M. de Lange: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
  • Abstract:

    Backgrounds

    Drug-target binding kinetics has received increasing interest in drug discovery, due to its influence on the time course of the drug effect.

    Aims

    In this study, we aim to determine how drug-target binding kinetics, target concentrations and tissue characteristics can be used to predict selectivity over time. 

    Methods

    We investigated the

    ..

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Last update 4 October 2019

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