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Attach or perish: culture morphology and causal factors for variable attachment properties of cryopreserved human hepatocytes

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ÖLANDER, Magnus (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
  • Co-author(s): Magnus Ölander: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Jacek Wisniewski: Department of Proteomics and Signal Transduction, Biochemical Proteomics Group, Max Planck Institute of Biochemistry, Martinsried, Germany
    Agneta Norén: Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:


    Cryopreserved human hepatocytes are the ‘gold standard’ for hepatic drug disposition studies. Cells from different donors show highly variable attachment properties, and the reasons are largely unclear. 


    To develop a ‘monolayer score’ for better classification of hepatocyte batches, and to use global proteomics for identifying causes


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Last update 4 October 2019

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