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Attach or perish: culture morphology and causal factors for variable attachment properties of cryopreserved human hepatocytes

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ÖLANDER, Magnus (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
  • Co-author(s): Magnus Ölander: Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Jacek Wisniewski: Department of Proteomics and Signal Transduction, Biochemical Proteomics Group, Max Planck Institute of Biochemistry, Martinsried, Germany
    Agneta Norén: Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    Cryopreserved human hepatocytes are the ‘gold standard’ for hepatic drug disposition studies. Cells from different donors show highly variable attachment properties, and the reasons are largely unclear. 

    Aims

    To develop a ‘monolayer score’ for better classification of hepatocyte batches, and to use global proteomics for identifying causes

    ..

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Last update 4 October 2019

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