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Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through downregulation of HIF-2α and inhibits tumor growth

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: CHEN, Lixia (Shenyang, China)
  • Co-author(s): Lixia Chen: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
    Hua Li: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
  • Abstract:

    Backgrounds

    Von Hippel-Lindau (VHL) protein is a member of an E3-ubiquitin ligase complex that target α subunits of hypoxia-inducible factors 1 and 2 (HIFα). The loss of VHL occurs in over 80% of clear cell Renal Cell Carcinoma (ccRCC). HIF-2α has been shown to be an oncogene in VHL-null RCC. Therefore, inhibition of HIF-2α expression would be an..

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Last update 4 October 2019

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