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Acute and delayed effects of cisplatin and methotrexate administration on intestinal substance P dynamics in rats

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: HIRAFUJI, Masahiko (School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Department of Pharmacological Sciences, Ishikari-Tobetsu, Japan)
  • Co-author(s): Saki Shiga: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Takuji Machida: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Mikiko Yutani: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Maiko Machida: Division of Pharmacotherapy, Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Hokkaido, Japan
    Kenji Iizuka: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Masahiko Hirafuji: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
  • Abstract:

    Backgrounds

    Intestinal substance P is considered to involve in the mechanism of cancer chemotherapy-induced nausea and vomiting.

    Aims

    The aim of this study was to compare the intestinal substance P metabolism after a single administration to rats of cisplatin or methotrexate, which have different emetogenicity in humans.

    Methods

    Rats were i.p. injected

    ..

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Last update 4 October 2019

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