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Effects of docosahexaenoic acid and resolvin D1 on pressure-induced reduction of iNOS and COX-2 expression in vascular smooth muscle cells.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: MACHIDA, Takuji (Health Sciences University of Hokkaido, Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Ishikari-Tobetsu, Hokkaido, Japan)
  • Co-author(s): Takuji Machida: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Tomoko Endo: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Mikiko Yutani: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Kenji Iizuka: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
    Masahiko Hirafuji: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
  • Abstract:

    Backgrounds

    We previously showed that docosahexaenoic acid (DHA) potentiates expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by interleukin-1β (IL-1β) in cultured rat vascular smooth muscle cells (VSMCs). 

    Aims

    In the present study, we investigated the potentiating effects of DHA and its metabolite, resolvin

    ..

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Last update 4 October 2019

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