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Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: OTAKA, Akira (Insutitute of Biomedical Sciences, Tokushima University, Japan, Tokushima, Japan)
  • Co-author(s): Akira Otaka: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
    Keisuke Aihara: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
    Tetsuro Yoshimaru: Institute for Genome Research, Tokushima University, Tokushima, Japan
    Akira Shigenaga: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
    Toyomasa Katagiri: Institute for Genome Research, Tokushima University, Tokushima, Japan
  • Abstract:

    Backgrounds

    A novel estrogen signaling regulator: brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3), which is overexpressed in a majority of breast cancers. BIG3 captures prohibitin 2 (PHB2) in the cytoplasm of cancer cells and inhibits the suppression of ERα signaling pathways. Based on these findings, ERα activity-regulator..

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Last update 4 October 2019

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