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Correlation between Formation of Glucuronide Metabolite and Covalent Protein Adducts of Nonsteroidal Anti-inflammatory Drugs

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: SHIMADA, Hiroaki (Kindai university, pharmacy, Higashi-osaka, Japan)
  • Co-author(s): Hiroaki Shimada: Department of Pharmacy, Kindai University, Osaka, Japan
    Atsushi Kawase: Department of Pharmacy, Kindai University, Osaka, Japan
    Taro Ogiso: Department of Pharmacy, Kindai University, Osaka, Japan
    Masahiro Iwaki: Department of Pharmacy, Kindai University, Osaka, Japan
  • Abstract:

    Backgrounds

    Nonsteroidal anti-inflammatory drugs (NSAIDs) sometimes cause idiosyncratic liver injury. Although previous studies have shown that complicated mechanisms are involved in NSAIDs-induced liver injury, glucuronide of NSAIDs (NSAIDs-Glu) plays important roles in developing liver injury. Especially, NSAIDs-Glu forms covalent binding with..

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Last update 4 October 2019

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