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Effects of glutathione depletion on diclofenac-induced cytotoxicity in mouse hepatocytes

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: KAWASE, Atsushi (Kindai University, Department of Pharmacy, Osaka, Japan)
  • Co-author(s): Atsushi Kawase: Department of Pharmacy, Kindai University, Osaka, Japan
    Ayaka Kaneto: Department of Pharmacy, Kindai University, Osaka, Japan
    Mao Ishibashi: Department of Pharmacy, Kindai University, Osaka, Japan
    Hiroaki Shimada: Department of Pharmacy, Kindai University, Osaka, Japan
    Masahiro Iwaki: Department of Pharmacy, Kindai University, Osaka, Japan
  • Abstract:

    Backgrounds

    Idiosyncratic drug-induced liver injury (DILI) with certain drugs is usually rare, but has serious consequences and is the most common reason for drugs to be withdrawn from the pharmaceutical market. It is difficult to predict its occurrence during preclinical and clinical trials, because the mechanisms of idiosyncratic DILI are still..

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Last update 4 October 2019

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