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High brain uptake of GABAA antagonist oroxylin A leads to lack of anxiolytic effect of Radix Scutellariae

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ZUO, Joan (The Chinese University of Hong Kong, School of Pharmacy, Shatin, Hong Kong SAR China)
  • Co-author(s): Sophia Fong: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
    Chenrui LI: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
    Yiu Cheong Ho: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
    Rui Li: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
    Qian Wang: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
    Eric Wong: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Xue: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
    Joan Zuo: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
  • Abstract:

    Backgrounds

    Although flavones from Radix Scutellariae (RS) were reported to have CNS activities with baicalein (B), wogonin (W) and baicalin (BG) identified to be positive modulators of the benzodiazepine binding site of GABAA receptors and oroxylin A (OA) to be a GABAA antagonist, their brain uptake has never been fully investigated. 

    Aims

    The

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Last update 4 October 2019

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