Menu
  • Join
  • Login
  • Contact
 

Search abstracts


Approaches to up-regulate P-glycoprotein for the treatment of Alzheimer's disease

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NEWMAN, Stephanie (Melbourne, Australia)
  • Co-author(s): Stephanie Newman: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Yijun Pan: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Jennifer Short: Drug Discovery Biology, Monash University, Melbourne, Australia
    Joseph Nicolazzo: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  • Abstract:

    Backgrounds

    P-glycoprotein (P-gp) at the blood-brain barrier (BBB) mediates the brain-to-blood clearance of β-amyloid (Aβ) and is down-regulated in Alzheimer's disease (AD). Interestingly, the mood-stabilising drug lithium, has been associated with a reduced incidence of AD in humans. In vitro studies indicate that lithium chloride (LiCl) can..

  • The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 4 October 2019

FIP Congresses