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Induction of Mitophagy-mediated Antitumor Activity with Folate-appended Methyl-β-cyclodextrin

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: MOTOYAMA, Keiichi (Kumamoto University, Graduate School of Pharmaceutical Sciences, Kumamoto, Japan)
  • Co-author(s): Keiichi Motoyama: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Nao Tanaka: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Yuki Yamashita: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Taishi Higashi: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Hidetoshi Arima: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;, Program for Leading Graduate School "HIGO (health life science: Interdisciplinary and Glocal Oriented) Program", Kumamoto University, Kumamoto, Japan
  • Abstract:

    Backgrounds

    size: small;">Mitophagy is the specific autophagic elimination of mitochondria, which regulates cellular survival via the removal of damaged mitochondria. Recently, we revealed that folate-appended methyl-βsize: small;">-cyclodextrin (FA-M-βsize: small;">-CyD) provided selective antitumor activity in folate receptor-αsize: small;"> (FR-α

    ..

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Last update 4 October 2019

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