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Development of Solute Carrier (SLC) Transporters Kidney Cell Models Using hTERT-immortalized Renal Proximal Tubule Epithelial Cells (RPTEC/TERT1)

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: GUALDONI, Sara (LGC-ATCC, Copenhagen, Denmark)
  • Co-author(s): Sara Gualdoni: standards division, LGC group, Copenhagen, Denmark
    Chaozhong Zou: ATCC Cell Systems, Gaithersburg, United States
  • Abstract:

    Backgrounds

    Kidney membrane transporters play a key part in drug disposition and renal clearance. Among the SLC families, OAT1, OCT2 and OAT3 are the most important transporters in kidney tissue recommended for drug interaction studies by the FDA and EMA. Unfortunately, primary RPTEC cells lose OAT1, OCT2 and OAT3 transporters expression in culture. ..

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Last update 4 October 2019

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